翻訳と辞書 Words near each other ・ Intra legem ・ Intra-aortic balloon pump ・ Intra-articular ligament of head of rib ・ Intra-company transfer ・ Intra-embryonic coelom ・ Intra-European Organisation of Tax Administrations ・ Intra-flow interference ・ Intra-frame ・ Intra-household bargaining ・ Intra-industry trade ・ Intra-organismic perspective ・ Intra-rater reliability ・ Intra-species recognition ・ Intrabeam scattering ・ Intrabody ・ Intrabody (protein) ・ Intracardiac injection ・ Intracavernous injection ・ Intracellular ・ Intracellular antibody-mediated degradation ・ Intracellular calcium-sensing proteins ・ Intracellular digestion ・ Intracellular parasite ・ Intracellular pH ・ Intracellular receptor ・ Intracellular transport ・ Intraclass correlation ・ Intraclasts ・ Intracluster medium ・ Intraco I Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Intrabody (protein) ： ウィキペディア英語版 Intrabody (protein) In molecular biology, an intrabody (from ''intracellular'' and ''antibody'') is an antibody that works within the cell to bind to an intracellular protein. Due to the lack of a reliable mechanism for bringing antibodies into the cell from the extracellular environment, this typically requires the expression of the antibody within the target cell, which can be accomplished by gene therapy. As a result, intrabodies are defined as antibodies that have been modified for intracellular localization, and the term has rapidly come to be used even when antibodies are produced in prokaryotes or other non-target cells. This term can apply to several types of protein targeting: the antibody may remain in the cytoplasm, or it may have a nuclear localization signal, or it may undergo cotranslational translocation across the membrane into the lumen of the endoplasmic reticulum, provided that it is retained in that compartment through a KDEL sequence. Because antibodies ordinarily are designed to be secreted from the cell, intrabodies require special alterations, including the use of single-chain antibodies (scFvs), modification of immunoglobulin VL domains for hyperstability, selection of antibodies resistant to the more reducing intracellular environment, or expression as a fusion protein with maltose binding protein or other stable intracellular proteins. Such optimizations have improved the stability and structure of intrabodies, allowing the publication of a variety of promising applications against hepatitis B, avian influenza, prion diseases, inflammation, Parkinson's disease, and Huntington's disease. == References == 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Intrabody (protein)」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.